GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1926657 | 1 | rs4520712 | chr13:95878940 | ABCC4 | chr13:95672084-95953687:- | -0.18 | -3.45 | 0.000609 | Breast cancer |
| THCA | cis | rs6479891 | 1 | rs4525102 | chr10:65086273 | LOC84989 | chr10:65224989-65226320:+ | -0.27 | -4.33 | 1.8E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs4525102 | chr10:65086273 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -4.66 | 4.04E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs17780086 | 1 | rs4525554 | chr17:30312819 | C17orf79 | chr17:30178885-30186326:- | -0.2 | -4.54 | 7.17E-6 | Height |
| THCA | cis | rs3730682 | 1 | rs4525561 | chr18:51835955 | POLI | chr18:51795849-51824602:+ | 0.18 | 5.29 | 1.85E-7 | Psoriasis |
| THCA | cis | rs12608504 | 1 | rs4531856 | chr19:18388383 | KIAA1683 | chr19:18367906-18385319:- | -0.27 | -7.94 | 1.47E-14 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs5743030 | 1 | rs4531962 | chr2:190526683 | ASNSD1 | chr2:190526125-190535556:+ | -0.76 | -8.25 | 1.55E-15 | Subcutaneous adipose tissue |
| THCA | cis | rs7267979 | 1 | rs453329 | chr20:25440593 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -7.04 | 6.61E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs453329 | chr20:25440593 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.5 | 0.000518 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs453329 | chr20:25440593 | FAM182B | chr20:25744102-25848786:- | 0.26 | 5.31 | 1.73E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs453329 | chr20:25440593 | NINL | chr20:25433338-25566153:- | -0.36 | -7.37 | 7.51E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs453329 | chr20:25440593 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.66 | 0.000282 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | ANKRD13B | chr17:27916801-27941778:+ | 0.37 | 9.07 | 3.02E-18 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | CORO6 | chr17:27941774-27948441:- | 0.52 | 12.22 | 4.41E-30 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | EFCAB5 | chr17:28256874-28435469:+ | 0.6 | 11.36 | 1.18E-26 | Coffee consumption (cups per day) |